Speed of onset of bronchodilator response to salbutamol inhaled via different devices in asthmatics: a bioassay based on functional antagonism
F Lavorini, P Geri, L Mariani, C Marmai… - British journal of …, 2006 - Wiley Online Library
Aims To evaluate the speed of onset of bronchodilation following salbutamol administered
via a metered‐dose inhaler with a spacer (pMDI+ Volumatic) and a dry‐powder inhaler
(Diskus), as well as the relative potencies of these devices in asthmatic patients with
methacholine‐induced bronchoconstriction. Methods Eighteen patients inhaled
methacholine (MCh) until FEV1 decreased by 35% of control. Following administration of
placebo, 200 µg salbutamol or 400 µg salbutamol through the pMDI+ Volumatic or the …
via a metered‐dose inhaler with a spacer (pMDI+ Volumatic) and a dry‐powder inhaler
(Diskus), as well as the relative potencies of these devices in asthmatic patients with
methacholine‐induced bronchoconstriction. Methods Eighteen patients inhaled
methacholine (MCh) until FEV1 decreased by 35% of control. Following administration of
placebo, 200 µg salbutamol or 400 µg salbutamol through the pMDI+ Volumatic or the …
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